When a man is ****ually aroused, nitric oxide is released in the penis, leading to the production of cyclic GMP (cGMP). This chemical causes the blood vessels to relax and widen, allowing more blood to flow into the penis, leading to an erection. PDE5 enzymes break down cGMP, limiting blood flow. Sildenafil inhibits PDE5, allowing cGMP to remain in the system longer, promoting enhanced blood flow and stronger erections.
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